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Home > Products >  High quality Indometacin

High quality Indometacin CAS NO.53-86-1

  • FOB Price: USD: 1.00-1.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,
  • Available Specifications:

    1(1-2)Kilogram

  • Product Details

Keywords

  • Indometacin
  • 53-86-1
  • Indometacin 53-86-1

Quick Details

  • ProName: High quality Indometacin
  • CasNo: 53-86-1
  • Molecular Formula: C19H16ClNO4
  • Appearance: White powder
  • Application: Used
  • DeliveryTime: 3 days
  • PackAge: sample package
  • Port: Qingdao Port
  • ProductionCapacity: 1000 Kilogram/Week
  • Purity: 99%
  • Storage: dry and cool
  • Transportation: By air
  • LimitNum: 1 Kilogram
  • Shelf life: 2 years
  • Application: Cosmetic Ingredient

Superiority

 We promise our customer following items

1.Reasonable price:
We provide high quality products with competitive price in china,

2.Low moq:
No worry about the low moq, our moq is 1 gram or lower.

3.Good and efficient service,Fast Delivery
Fast respond save client's time, we promise to reply inquiry in 24 hours including holidays and send quotation sheet and other documents in 48 hours.

4.Super-good quality
We have strict quality control system .Good reputation in Market

Contact us

If you have any further questions or need a sample,Please do not hesitate to contact us.

Leah| Senior Sales | Qingdao Sigmachemical Co.,Ltd
| Wechat/Whatsapp/Skype/Phone Number. +86 186 63970593
| Email:sales@sigmachemical.com.cn
| Address:No 70,Shandong Road,Qingdao city,China 

Details

Product Description

 

 

Specifciation:

                             1.Competitive price
                             2.Fast Delivery Within 2 days
                             3.SGS , BV, GMP,ISO approve
                             4.Professional factory

      Product Description

 
  Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.

   Certification of Analysis

 

Product Name

Indomethacin

MFG. Date

Dec.12.2015

Batch NO.

HS13-068

EXP. Date

Dec.11.2018

Batch quantity

300kg

Analysis Date

Dec.18.2015

Standard

BP2005

Items

Specification

Results

Characters

White crystalline powder ,parctically   insoluble in water, sparingly soluble in alcohol

Conforms

Identification

 

 

A.Melting point

158-162°C

158.5-160.0°C

B.Absorption at 318nm

170-190

185.19

C.

Conforms to the requirement

Conforms

D.

Conforms to the requirement

Conforms

E.

Conforms to the requirement

Conforms

Related substances(TLC)

Not more than 0.5%

<0.5%

Heavy metals

Not more than 20ppm

<20ppm

Loss on drying

Not more than 0.5%

0.13%

Sulphated Ash

Not more than 0.1%

0.07%

Assay

98.5%-100.5%

99.8%

Conclusion:Complies with EP7

                          Function&Application

Indometacin (INN and BAN) or indomethacin (AANUSAN and former BAN) is a non-steroidal anti-inflammatory drug(NSAID) commonly used as a prescription medication to reduce feverpain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms.

It is marketed under more than twelve different trade names.

 

Clinical indications for indometacin include:

  • ankylosing spondylitis
  • arthritic gout
  • Bartter syndrome
  • bursitis
  • cryoglobulinemia
  • dysmenorrhea (menstrual cramps)
  • fever and pain associated with malignant diseases (especially tumor fever associated with liver involvement, lymphogranulomatosis)
  • headaches caused by the Valsalva maneuver
  • hemicrania continua
  • hypnic headache
  • juvenile arthritis
  • migraine
  • nephrogenic diabetes insipidus (prostaglandin inhibits vasopressin's action in the kidney)
  • osteoarthritis
  • Paget's disease of bone
  • paroxysmal hemicrania
  • patent ductus arteriosus
  • pericarditis
  • primary exertion headache
  • primary stabbing headaches
  • pseudogout
  • psoriatic arthritis
  • reactive arthritis
  • renal colic (pain due to kidney stones)
  • retinopathy of prematurity
  • rheumatoid arthritis
  • tendinitis
  • trigeminal autonomic cephalgias

Indometacin has also been used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to close patent ductus arteriosus.

Indometacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The medication is better described as an anti-inflammatory, rather than an analgesic. Indometacin can also affect warfarin and subsequently raise INR.

Our Advantages
             
 
1.Competitive price
2.Fast Delivery Within 3 days
3.SGS,BV,GMP,ISO approve
4.Professional factor

 

Company Information
Qingdao Sigma Chemical Co., Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Sigma is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

Sigma has become the "Top 500 Chinese manufactur
Packaging & Shipping

Our Services

 

 

 

FAQ

Q1: Are you a manufacturer

Answer: Yes, we are factory founded on 2002.

Q2: How to contact with us
Click the Alibaba "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.

Q3:Which kind of payment terms do you accept
For small order,you can pay by T/T, or Paypal,nomal order by T/T to our company account

Q4:Can you give me a discount price
Surely,It depend on your qty

Q5:How can i get a sample
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q6: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

If you are interested,welcome to contact with us.
Pls send message if you are interested,click "send" as below ^.^

 

 
 

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