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Home > Products >  High Quality Ademetionine disulfate tosylate

High Quality Ademetionine disulfate tosylate CAS NO.97540-22-2

  • FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
  • Min.Order: 1 Gram
  • Payment Terms: L/C,D/A,D/P,T/T,MoneyGram
  • Available Specifications:

    1(1-2)Gram

  • Product Details

Keywords

  • 97540-22-2
  • Ademetionine disulfate tosylate
  • Ademetionine disulfate tosylate Price

Quick Details

  • ProName: High Quality Ademetionine disulfate to...
  • CasNo: 97540-22-2
  • Molecular Formula: C22H34N6O16S4
  • Appearance: White powder
  • Application: pharmaceutical intermediates
  • DeliveryTime: Qingdao Port
  • PackAge: 1kg or 25Kg drum
  • Port: QIngdao Port
  • ProductionCapacity: 3000 Metric Ton/Year
  • Purity: 98% HPLC
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: By air or by sea. Prompt delivery
  • LimitNum: 1 Gram
  • Moisture Content: See data sheet
  • Samples: Available

Superiority

 Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
 
The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
 
QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details

S-Adenosyl-l-methionine Disulfate Tosylate (SAM Tfor short) is a common cosubstrate involved in methyl 

group transfers. SAMe was first discovered in Italy by G. L. Cantoni in 1952, can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain of osteoarthritis, is now universerally acknowleged as an important pharmaceuticals to treat liver diseases. Nowaday it is commonly used in pharmaceuticals, health care food industry both at domestic and international market. 

Name

Ademetionine disulfate tosylate

Synonyms

S-Adenosyl-L-methionine disulfate tosylate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine disulfate 4-methylbenzenesulfonate

Brand

Qindgao Sigma Chemical Co.,Ltd

Molecular Formula

C15H22N6O5S.2(H2SO4).C7H8SO3

Molecular Weight

766.79

CAS Registry Number

97540-22-2

 

Appearance

Almost white crystal/powder,hygroscopic

Consistent

Identification

(IR)

Positive

Water content (K.F.)

2.0% max

1.38%

Solubility

Soluble in water

Consistent

PH (so 1.5)

1.0-2.0

1.29

Ademethionine ion (HPLC)

40.0%min (as anhydrous)

44.52%

(S,S-Enantiomers)

60%min (as area%)

79.30%

p-Toluenesulfonic acid (HPLC)

21-24% (as anhydrous)

32.51%

Sulfates

23.5-26.5% (as anhydrous)

22.20%

Purity(HPLC)

95%min

99.23%

Related Substances(HPLC)

The sum area of unknown impurities must be not more than 1.5 times of reference solution main peak’s (1.5%)

0.10%

Adenosine

0.5%max (as area%)

0.04%

Methylthioadenosine

1.5%max (as area%)

0.47%

S-Adenosyl-L-Homocystsine

0.5%max (as area%)

0.01%

Heavy metals

10ppm

Consistent

E.coli

Negative

Consistent

Salmonella

Negative

Consistent

Sulphated ash

0.5%max

0.16%

Microbiological

1000CFU/g max

23CFU/g

CONCLUSION: The results of all the analysis items are up to standard

Function

1. S-Adenosyl-l-methionine Disulfate Tosylate (SAM-T) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

 

2. The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.

 

3. In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.

The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases (EC 2.1.1) that use SAM as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (EC 2.1.1.13 or EC 2.1.1.14). This methionine can then be converted back to SAM, completing the cycle.

 

4. Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

 

5. SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.

 

6. In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. All other indications are not yet proven.

 

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