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Home > Products >  High Quality Epalrestat

High Quality Epalrestat CAS NO.82159-09-9

  • FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
  • Min.Order: 1 Gram
  • Payment Terms: L/C,D/A,D/P,T/T,MoneyGram
  • Available Specifications:

    1(1-2)Gram

  • Product Details

Keywords

  • 82159-09-9
  • Epalrestat
  • Epalrestat Price

Quick Details

  • ProName: High Quality Epalrestat
  • CasNo: 82159-09-9
  • Molecular Formula: C15H13NO3S2
  • Appearance: orange red crystalline power
  • Application: pharmaceutical intermediates
  • DeliveryTime: Qingdao Port
  • PackAge: 1kg or 25Kg drum
  • Port: QIngdao Port
  • ProductionCapacity: 3000 Metric Ton/Year
  • Purity: 98% HPLC
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: By air or by sea. Prompt delivery
  • LimitNum: 1 Gram
  • Moisture Content: See data sheet
  • Samples: Available

Superiority

 Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
 
The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
 
QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details

Supply 99% API High quality raw material epalrestat 82159-09-9

Information

Product Name epalrestat

Molecular Formula C15H13NO3S2

Molecular Weight 319.3986

CAS Registry Number 82159-09-9

Density 1.43g/cm3

Boiling point 516.8°C at 760 mmHg

Refractive index 1.705

Flash point 266.4°C                                        

Epalrestat is an aldose reductase inhibitor, used in the treatment of diabetic neuropathy.

Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes. Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group. Aldose reductase is the key enzyme in the polyol pathway whose enhanced activity is the basis of diabetic neuropathy. Aldose reductase inhibitors (ARI) target this enzyme. Out of the many ARIs developed, ranirestat and fidarestat are in the trial stage. Others have been discarded due to unacceptable adverse effects or weak efficacy. Epalrestat is the only ARI commercially available. It is easily absorbed into the neural tissue and inhibits the enzyme with minimum side effects.

Function

Epalrestat is an aldose reductase inhibitor. Long-term treatment with epalrestat is well tolerated and can effectively delay the progression of diabetic neuropathy and ameliorate the associated symptoms of the disease, particularly in subjects with good glycemic control and limited microangiopathy.

1. Epalresta is an aldose reductase inhibitor that acts reversibly to inhibit aldose reductase that converts glucose to sorbitol. It is used for the improvement of symptoms, abnormal vibrational sensation, abnormal heartbeat caused by diabetic nerve ending disorders.
2. Epalrestat is used to prevent and treat diabetes.

Epalrestat is an aldose reductase inhibitor.
"Long-term treatment with epalrestat is well tolerated and can effectively delay the progression of diabetic neuropathy and ameliorate the associated symptoms of the disease, particularly in subjects with good glycemic control and limited microangiopathy."

Specification

Test Item

Test Specification

Description

Orange to orange red crystalline power

 

Solubility

Hardly soluble in water, slightly soluble in methanol, ethanol, acetone,easily soluble in tetrahydrofuran

Indentification

Must meet

LOD(105℃ for 3hrs)

NMT0.5%

 Residue on Ignition

NMT0.1%

RelatedSubstances(By HPLC)

Individual impurity: NMT 0.5%

Total impurities: NMT 1.0%

Assay(By HPLC)

98.0-102.0% ON DB

Melting Point

222-227℃

Heavy Metals

NMT 20ppm

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