China (Mainland)
High Quality Toradol CAS NO.74103-07-4
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram
- Available Specifications:
1(1-2)Gram
- Product Details
Keywords
- 74103-07-4
- Toradol
- Toradol Price
Quick Details
- ProName: High Quality Toradol
- CasNo: 74103-07-4
- Molecular Formula: C8H11NO4S2
- Appearance: White powder
- Application: pharmaceutical intermediates
- DeliveryTime: Qingdao Port
- PackAge: 1kg or 25Kg drum
- Port: QIngdao Port
- ProductionCapacity: 3000 Metric Ton/Year
- Purity: 98% HPLC
- Storage: Store in dry, dark and ventilated plac...
- Transportation: By air or by sea. Prompt delivery
- LimitNum: 1 Gram
- Moisture Content: See data sheet
- Samples: Available
Superiority
We promise our customer following items
1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality
Details
Supply Toradol, Ketorolac Tromethamine 74103-07-4
Product Description
Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC50 of 0.10 μM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC50 of > 100 μM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC50 of 0.025 μM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC50 of 0.039 μM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 μM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.
Specification
|
TESTS |
SPECIFICATIONS |
RESULTS |
|
Appearance |
White or almost white, crystalline powder |
Almost white crystalline powder |
|
Solubility |
Freely soluble in water and in methanol; slightly soluble in alcohol, in dehydrated alcohol, and in tetrahydrofuran; practically insoluble in acetone, in dichloromethane, in toluene, in ethyl acetate,in dioxane,in hexane,in butyl alcohol,and acetonitrile |
Conforms |
|
Identification |
UV:Maximum absorption at 243nm,318nm.Minimum absorption at 268nm |
Conforms |
|
TLC:color and position of principal spot obtained with test solution consistent with that of the reference solution |
Conforms |
|
|
IR |
Conforms |
|
|
pH |
5.7~6.7 |
6.1 |
|
Melting range |
165~170°C |
166~168°C |
|
Clarity and color of solution |
The solution should be clear and colorless ,if not ,not more intensely turbid than No.1 reference solution and not more intensely colored than reference solution of Y1 |
Conforms |
|
Related substances |
1-ketone-ketorolac acid≤0.1% |
0.0027% |
|
1-hydroxyl-ketorolac acid≤0.1% |
N.D |
|
|
Other single impurity≤0.5% |
0.12% |
|
|
Total impurities≤1.0% |
0.17% |
|
|
Dichloromethane |
Peak area of dichloromethane in test solution is not more than that of reference solution |
N.D |
|
Loss on drying |
≤0.5% |
0.08% |
|
Residue on ignition |
≤0.1% |
0.09% |
|
Heavy metals |
≤0.002% |
Conforms |
|
Assay (on the dried basis) |
98.5~101.5% |
99.2% |
|
Conclusion |
The product meets the requirements of USP |
|
Function and Application
Ketorolac is indicated for short-term management of moderate to severe pain. Concerns about the high incidence of reported side effects led to restriction in its dosage and maximum duration of use. In the UK, treatment should be initiated only in a hospital. Maximum duration of treatment should not exceed five days for tablets (per package insert), or two days for continuous daily dosing with intravenous or intramuscular formulations. The ophthalmic formulation can be used instead of steroidal anti inflammatories in cases where a raised intraocular pressure (glaucoma) is to be avoided.
Packing and Storage
1kg with double plastic container inside/Aluminum foil bag ;
25kg with double plastic container inside/Fiber drum outside.Or as your request.
Shipped in 3 days after payment.
1.Stored in a cool and dry well-closed container and in ventilated area.
2.kept away from moisture and strong light or high temperature.
3.Two years under well storage situation and stored away from direct sun light.
