Genipin is a chemical compound found in gardenia fruit extract. It is an aglycone derived from an iridoidglycoside called geniposide present in fruit of Gardenia jasminoides.

Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking.[1] It has a low acute toxicity, with LD50 i.v. 382 mg/kg in mice, therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking reagents.Furthermore, genipin can be used as a regulating agent for drug delivery, as the raw material for gardenia blue pigment preparation, and as the intermediate for alkaloidsyntheses

Nettle is a plant in the Urticaceae family that is more commonly known as Urtica dioica, or stinging nettle. This plant is native to Eurasia and has also been found growing on the North American continent in the wilderness. Stinging nettle is a perennial plant that grows in large patches and prefers rich, moist soil. Its leaves are serrated and heart-shaped with stems that are covered in prickly hairs that, if came into contact with, can cause painful stinging on the skin.