Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

 

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

 

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

 

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

 

 

 

 

 

TEST ITEMS	SPECIFICATION	Method
Appearance	White crystals or a white crystalline powder	White powder
Identification	1) Corresponds to that of Bisoprolol Fumarate reference standard.	Conforms
	2) The retention time of the major peak in the chromatofram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation as obtained in the Assay.	Conforms
Specific rotation	-2°~ +2°	0°
Water determination	≤ 0.5%	0.1%
Reside on ignition	≤ 0.1%	0.03%
Heavy metals	≤ 0.002%	<0.002%
Chromatographic purity	Total impurities ≤ 0.5%	0.43%
Content of Fumaric Acid	14.8 ~ 15.4% calculated on the anhydrous basis	15.1%
Residual Solvents	2-propanol ≤ 5000ppm	196ppm
	Epichlorohydrin ≤ 100ppm	ND
	Benzene ≤ 2ppm	ND
	Methanol ≤ 3000ppm	ND
	Methyl tertbutyl ether ≤ 5000ppm	ND
	Ethanol ≤ 5000ppm	ND
	Ethyl acetate ≤ 5000ppm	ND
Assay	97.5% ~ 102.0% calculated on the anhydrous basis	100.2%
Conclusion:Complies with USP39

 

Bisoprolol Fumarate is a beta blocker, which has high affinity for the beta 1 receptor of bronchi and vascular smooth muscle, which can dilate blood vessels and reduce blood pressure. Apply to hypertension, coronary heart disease, and moderate to severe chronic stable heart failure and so on.