High Quality Diisopropylammonium dichloroacetate CAS NO.660-27-5

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Keywords

660-27-5
Diisopropylammonium dichloroacetate
Diisopropylammonium dichloroacetate Price

Quick Details

ProName: High Quality Diisopropylammonium dich...
CasNo: 660-27-5
Molecular Formula: C8H17Cl2NO2
Appearance: White powder
Application: pharmaceutical intermediates
DeliveryTime: Qingdao Port
PackAge: 1kg or 25Kg drum
Port: QIngdao Port
ProductionCapacity: 3000 Metric Ton/Year
Purity: 98% HPLC
Storage: Store in dry, dark and ventilated plac...
Transportation: By air or by sea. Prompt delivery
LimitNum: 1 Gram
Moisture Content: See data sheet
Samples: Available

Superiority

Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

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2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
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4.Super-good quality

Details

High Purity Diisopropylamine Dichloroacetate 99% Powder CAS 660-27-5

Product Name: Diisopropylamine Dichloroacetate
Purity: 99%
CAS No.: 660-27-5
Molecular Formula: C8H17O2NCL2
Molecular Weight: 230.1321
Appearance: White crystalline powder

Function

Diisopropylammonium dichloroacetate (DIPA) was found to exert a significant and prolonged hypoglycemic effect in alloxan diabetic rats, but did not alter blood sugar levels of normal rats. It did not affect blood glycerol levels in either the diabetic or nondiabetic group.
Both DIPA and sodium dichloroacetate (DCA) significantly stimulated glucose-U-14C oxidation to 14CO2 in isolated hemidiaphragms from diabetic but not from nondiabetic rats. Diisopropylammonium hydrochloride (DIA) was not effective in promoting glucose oxidation in tissues from diabetic or nondiabetic rats. Thus, the effect of the compound in vivo may be due entirely to its acid moiety.
DCA (and presumably DIPA) produced no significant changes in glycerol output or on glucose-U-14C conversion to 14C-triglyceride in hemidiaphragms or epididymal fat pads from normal or diabetic rats. In addition, DCA did not alter oleate-1-14C conversion to 14C-triglyceride in muscle or adipose tissue from diabetic animals. However, DCA markedly inhibited oleate-1-14C oxidation to 14CO2 in muscle from diabetic rats.
It is possible that the hypoglycemic activity of DIPA, and presumably DCA, may be due, at least partly, to a suppression of fatty acid oxidation in muscles of diabetic rats. The high levels of circulating free fatty acids and ketone bodies which commonly occur in diabetes increase intracellular concentrations of citrate, a known inhibitor of phosphofructokinase (PFK). By suppressing fatty acid oxidation in muscle, DIPA and DCA may thus reduce citrate levels and reactivate PFK. Such an effect may explain the selective action of both DIPA and DCA on diabetic but not on normal tissue.