China (Mainland)
High Quality Methotrexate CAS NO.59-05-2
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
1(1-2)Gram
- Product Details
Keywords
- 59-05-2
- Methotrexate
- Methotrexate Price
Quick Details
- ProName: High Quality Methotrexate
- CasNo: 59-05-2
- Molecular Formula: C20H22N8O5
- Appearance: White powder
- Application: pharmaceutical intermediates
- DeliveryTime: Qingdao Port
- PackAge: 1kg or 25Kg drum
- Port: QIngdao Port
- ProductionCapacity: 3000 Metric Ton/Year
- Purity: 98% HPLC
- Storage: Store in dry, dark and ventilated plac...
- Transportation: By air or by sea. Prompt delivery
- LimitNum: 1 Gram
- Moisture Content: See data sheet
- Samples: Available
Superiority
Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.
We promise our customer following items
1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality
Details
Product Description
Description
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.
specification
| Text | USP27 | EP4 | BP2002 |
| Assay% | 98.0-102.0 | 98.0-102.0 | 98.0-102.0 |
| Residue on ignition% | ≤0.1 | ||
| Specific roataion | +19-+24 | +19-+24 | |
| Loss on drying% | |||
| Chromatographic purity% | ≤2.0(total) | ||
| ≤0.5(individual) | |||
| Water% | ≤12.0 | ≤13.0 | ≤12.0 |
| Organic Volatile impurites | conforms | ||
| Sulphated ash% | ≤0.1 | ≤0.1 | |
| Heavy metals ppm | 50 | 1 | |
| Related substance | |||
| Total | ≤1.3 | ≤1.3% | |
| Individual | At most five peaks | At most five peaks | |
| Impurity A% | ≤0.5 | ≤0.5 | |
| Impurity B% | ≤0.5 | ≤0.5 | |
| Impurity C% | ≤0.5 | ≤0.5 | |
| Impurity D% | ≤0.5 | ≤0.5 | |
| Impurity E% | ≤0.5 | ≤0.5 | |
| Unknown Impurity % | ≤0.5 | ≤0.5 | |
| (R)-Methotrexate% | ≤3.0 | ≤3.0 | |
