High Quality Monensin CAS NO.17090-79-8

 Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

 

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

 

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

 

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

· Introduction:

· Monensin is a polyether antibacterial agent, extracted from fermentation broth of Streptomyces Cinnamonensis. It has the antagonistic activity against fowl coccidiosis. Besides, it can also be used to promote the growth of fattening beef castles and lambs, to increase lactation of the dairy cows.

·   Monensin is a polyether antibiotic of the ionophore group. It exerts an anticoccidial action against Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix in chickens, affecting the trophozoites in the first stage of schizogony. Its action is connected with the formation of lipophilic complexes with monovalent ions (sodium and potassium), making the membranes of the coccidial cells permeable to the ions mentioned; hence the active sodium and potassium transport is disturbed. Sodium and chloride are accumulated into the cells of the parasites, drawing water into the sporosoites, causing their swelling and rupture. It hinders the maturing of the schizonts and the development of merozoites. An additional influence is the impeded transport of carbohydrate and the active sporozoite glycolysis provoked by monensin. When orally administered to ruminants (with developed forestomachs), monensin modifies ruminal metabolism, directing it predominantly to the formation of the energetically richer propionic acid (at the expense of the other volatile fatty acids – acetic acid, lactic acid), and to inhibition of protein degradation in the rumen as a result of which feed conversion efficiency is improved and the weight gain is increased. Monensin suppresses also the formation of methane genesis of the ruminants and inhibits its eructation out of the forestomachs which spares energy losses.

· Function:

·   For increased  rate  of  weight  gain; for  the  prevention  and  control of  coccidiosis  due  to Eimeria  bovis  and  Eimeria  zuernii  in  growing  cattle  on  pasture  or  in  dry  lot(stocker  and  feeder cattle  and  dairy  and  beef  replacement  heifers).

· Specification:

Product	MONENSIN
Test basis	USP33
Items		Specification	Results
Characters		white crystal powder	white crystal powder
Loss on drying		Not more than 4.0%	1.96%
Content of Monensin A and B activity		The percentage of Monensin A activity is not less than 90%.	94.9%
		The percentage of Monensin A and B activity is not less than 95%.	99.1%
Assay		≥800 µg/mg	902.3 µg/mg
Conclusion		This batch conforms to the monograph MONENSIN of USP33.