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Home > Products >  High Quality Donepezil/Donepezil hcl

High Quality Donepezil/Donepezil hcl CAS NO.120014-06-4

  • FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
  • Min.Order: 1 Gram
  • Payment Terms: L/C,D/A,D/P,T/T,MoneyGram
  • Available Specifications:

    1(1-2)Gram

  • Product Details

Keywords

  • 120014-06-4
  • Donepezil
  • Donepezil hcl Price

Quick Details

  • ProName: High Quality Donepezil/Donepezil hcl
  • CasNo: 120014-06-4
  • Molecular Formula: C24H27NO3
  • Appearance: White powder
  • Application: pharmaceutical intermediates
  • DeliveryTime: Qingdao Port
  • PackAge: 1kg or 25Kg drum
  • Port: QIngdao Port
  • ProductionCapacity: 3000 Metric Ton/Year
  • Purity: 98% HPLC
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: By air or by sea. Prompt delivery
  • LimitNum: 1 Gram
  • Moisture Content: See data sheet
  • Samples: Available

Superiority

 Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
 
The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
 
QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details

 Product Description

Product name                Donepezil

Appearance:                  White or off-white crystalline powder

CAS NO.                       120014-06-4

Molecular Formula         C24H29NO3

Molecular Weight           379.49200

Melting point                  207ºC

Boiling point                   527.9ºC at 760mmHg

Density                          1.141g/cm3

Flash point                     273.1ºC

Donepezil hydrochloride is a therapeutic treatment of Alzheimer's drugs,compared with similar drugs have a low incidence of adverse reactions and efficacy obvious feature is the only way to reach the U.S. Food and Drug Administration standard treatment guidelines for Alzheimer's disease drug, is the only one species while the FDA approved the listing of new drugs and UK MCA for the treatment of mild to moderate Alzheimer's.

                                               

   Certification of Analysis

 

 

TESTS

RESULTS

SPECIFICATIONS

APPEARANCE

Complies

White or almost white crystalline powder

IDENTIFICATION

Complies

A: By IR, To match with working standard

 

Complies

B: By UV, To match with working standard.

TEST

Melting point

91℃-94℃

90℃-94℃

Residue on ignition

0.18%

≤ 0.2%

Heavy metals

< 0.001%

≤ 0.001%

Related substances

0.07%

≤ 1.0%

Water

0.11%

≤ 1.0%

ASSY

99.63%

≥99.0%

 

 

                          Function&Application

Function 

Mild or moderate Alzheimer-type dementia treatment.

Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs.

AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons,such cholinergic theory has been confirmed by histological study. Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites.

Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide,neurotransmitter receptors, or Ca2 + channels.

Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger,it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect,probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine.

 

Application

1. adult / elderly: initial treatment dosage 5mg / day (day 1). The product should be orally at bedtime at night. 

Doses of 5mg / day should be maintained at least - months to evaluate early clinical response, and donepezil hydrochloride reach steady-state plasma concentrations. After using 5mg / day treatment a month, making clinical evaluation may be the product of the dose to 10mg / day (day 1). The maximum recommended dose is 10mg.

Greater than 10mg / day dose clinical trials have not done. We did not conduct placebo-controlled clinical trials with more than six months. After stopping treatment, the efficacy of the product gradually diminishes. Discontinuation of treatment no rebound phenomenon.

2. liver and kidney damage: For mild to moderate renal and hepatic dysfunction, donepezil hydrochloride elimination is not affected, so these patients can use a similar dose schedule.

Our Advantages
             
 
1.Competitive price
2.Fast Delivery Within 3 days
3.SGS,BV,GMP,ISO approve
4.Professional factory

 

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