High Quality 2H-Indol-2-one,4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1) CAS NO.91374-20-8

 Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

 

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

 

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

 

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

Name	Ropinirole hydrochloride
Synonyms	4-(2-Dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride
Brand	Qindgao Sigma Chemical Co.,Ltd
Molecular Formula	C16H24N2O.HCl
Molecular Weight	296.84
CAS NO	91374-20-8

 

Ropinirole is a non-ergoline dopamine agonist. It is used in the treatment of Parkinson's disease. Ropinirole is also one of two medications in the United States (U.S.) with a Food and Drug Administration (FDA) approved indication for the treatment of restless legs syndrome (RLS), the other being pramipexole. The discovery of the drug's utility in RLS has been used as a successful example of drug repurposing.

Ropinirole's patent expired in May 2008, and the drug is now available in generic form.

Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, muscarinic, α1, and β-adrenoreceptors.

Ropinirole is metabolized primarily by cytochrome P450 CYP1A2, and at doses higher than clinical, is also metabolized by CYP3A4. At doses greater than 24 mg, CYP2D6 may be inhibited, although this has only been tested in vitro. 

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