High Quality Daunorubicin hydrochloride CAS NO.23541-50-6

Daunorubicinis the first generation of anthracycline antitumor antibiotics. The mechanism resembles doxorubicin. As a cycle non-specific chemotherapy drugs, daunorubicin spectrum anti-tumor doxorubicin far more narrow, for Solid Tumors great as doxorubicin and epirubicin.

Daunorubicin is a clinical first-line anti-cancer drug, is widely used in the clinical treatment of cancer. However, in human liver widespread carbonyl reductase 1 daunorubicin can be converted into a new alcohol metabolite daunorubicin alcohol. This new generation of alcohol metabolites not only lower than the anti-tumor activity of daunorubicin, but also toxic to the heart, resulting in myocardial cell injury.

The metabolic characteristics of daunorubicin greatly limits its clinical application. If we can find a carbonyl reductase inhibitors, not only can improve the clinical efficacy of daunorubicin and other anthracycline anticancer drugs, but also can reduce the toxic side effects of daunorubicin.

1, Daunorubicin can only be used for intravenous injection, because of venous irritation, can cause thrombophlebitis, it should not drip. If redness, pain or spills, immediately stop and take appropriate measures, such as a cold compress.

2, can not be performed during the FDA radiotherapy, especially thoracic radiotherapy. Disable least 3-4 weeks after radiotherapy to apply daunorubicin.

3, during the treatment and should be monitored before each chemotherapy, blood and heart function, regular liver and kidney function tests.

4, the product in animals can cause reproductive dysfunction and obstacles delayed. In male dogs can cause testicular atrophy.

5, during the treatment, and when reduction in peripheral blood leukocytes forbidden line of dental surgery (including dental extraction), when there are more natural when thrombocytopenia. (6) The daily medication to ensure adequate urine output, daily dose should Zhuojia drugs such as allopurinol in gout patients when the FDA.

6, should be measured cardiac function (including electrocardiogram, echocardiogram, serum enzymes such as aspartate aminotransferase, alanine aminotransferase, LDH and CPK, etc.) before treatment, such as to monitor LVEF (left conditional ventricular ejection index) and the ratio of PEP and LVEF, the most effective understanding of cardiac function, of course, is not as sensitive to myocardial biopsy.