Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

 

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

 

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

 

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

 

 

 

Item	Specification	Result
Appearance	White or almost white crystalline powder	white crystalline powder
Identification IR HPLC UV	Must conform to reference standard Must conform to reference standard Must conform to reference standard	Conforms Conforms Conforms
Water	≤0.5%	0.18%
Residue On Ignition	≤0.1%	0.06%
Heavy Metals	≤0.001%	<0.001%
Related Compounds Olmesartan RRT 0.2 Olmesartan medoxoil related compound A. RRT 0.7	≤0.5% ≤0.1%	0.2% 0.14%
Assay	98.5%~101.5% on the anhydrous and solvent-free basis	99.5%
Conclusion	The results conforms with USP35 standards

 

 

 

 

 

 

Function                   

Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. It works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle; it is therefore independent of angiotensin II synthesis pathways, unlike ACE inhibitors. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion. As a result of this blockage, olmesartan reduces vasoconstriction and the secretion of aldosterone. This lowers blood pressure by producing vasodilation, and decreasing peripheral resistance.

 

Application

Olmesartan is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.[2] The U.S. Food and Drug Administration (FDA) has determined that the benefits of Benicar continue to outweigh its potential risks when used for the treatment of patients with high blood pressure according to the drug label.