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Home > Products >  High Quality Fasudil hydrochloride

High Quality Fasudil hydrochloride CAS NO.105628-07-7

  • FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
  • Min.Order: 1 Gram
  • Payment Terms: L/C,D/A,D/P,T/T,
  • Available Specifications:

    1(1-2)Gram

  • Product Details

Keywords

  • 105628-07-7
  • Fasudil hydrochloride
  • Fasudil hydrochloride Price

Quick Details

  • ProName: High Quality Fasudil hydrochloride
  • CasNo: 105628-07-7
  • Molecular Formula: C14H18ClN3O2S
  • Appearance: White powder
  • Application: pharmaceutical intermediates
  • DeliveryTime: Qingdao Port
  • PackAge: 1kg or 25Kg drum
  • Port: QIngdao Port
  • ProductionCapacity: 3000 Metric Ton/Year
  • Purity: 98% HPLC
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: By air or by sea. Prompt delivery
  • LimitNum: 1 Gram
  • Moisture Content: See data sheet
  • Samples: Available

Superiority

 Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
 
The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
 
QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details


 

 

Product Information

 

Product Name: Fasudil hydrochloride
Appearance: White Crystalline Powder

M.F.: C14H18ClN3O2S

M.W.: 327.83

CAS NO.: 105628-07-7
EINECS NO.: 105628-07-7

Fasudil hydrochloride is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.

Specification 

Solution

 Easily solution in water, solution in methanol

Appearance

White or off-white crystalline powder

Assay

99%min

 Indentification

 

 UV

 Meets the requirements

 IR

 Consistent with reference specturm

 Chemical reaction

 Meets the requirements

 Color or solution

 not more intensely colored than refrence solution  Y1

 Clarify of solution

 not more palescent than refrence suspension solution 

Related substance

single impurity: 0.1%max
 

Total impurity:1.0%max

PH

4.5-6.0

Dimethylformamide

0.088%max

Aether

0.5%max

Methanol

0.3%max

Dichloromethane

0.06%max

Moisture

2.5%max

Residue on ignition

0.1%max

Heavy metals

0.002%max

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